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Chemical structure of tacrine Tacrine occurs as parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was a 1st centrally-acting cholinesterase inhibitor approved for the professional assistance of Alzheimer's disease, and was first synthesised at the Department of Pharmacology at the University of Sydney.

Clinical uses
Tacrine was a archetypical cholinesterase inhibitor for the professional assistance of Alzheimer's disease. Its clinical effectiveness was hindered by unfortunate unwritten bioavailability and considerable adverse drug reactions (including nausea, diarrhoea, urinary incontinence, and hepatotoxicity) such that few patients may tolerate alterative drugs. Indeed there exists a bit of doubt when to its efficaciousness around human being the least bit.

More recently cholinesterase inhibitors, such as donepezil, are at present favorite above tacrine.

Sources
Brenner, G. M. (2000). Pharmacological medicine. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6

Tacrine - familydoctor.org
Information for patients in English and Spanish.

Cognex
Full prescribing information from RxList.




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